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Pittsburgh compound...
Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study.
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- Degerman Gunnarsson, Malin (author)
- Uppsala universitet,Geriatrik
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- Lindau, Maria (author)
- Uppsala universitet,Stockholms universitet,Psykologiska institutionen,Geriatrik
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- Wall, Anders (author)
- Uppsala universitet,Enheten för nuklearmedicin och PET
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Darreh-Shori, T (author)
- Karolinska Institutet
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- Basu, Samar (author)
- Uppsala universitet,Oxidativ stress och inflammation
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- Nordberg, A (author)
- Karolinska Institutet
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- Larsson, Anders (author)
- Uppsala universitet,Geriatrik
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- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
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Basun, H (author)
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- Kilander, Lena (author)
- Uppsala universitet,Geriatrik
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(creator_code:org_t)
- 2010-03-20
- 2010
- English.
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In: Dementia and geriatric cognitive disorders. - Basel : S. Karger AG. - 1421-9824 .- 1420-8008. ; 29:3, s. 204-12
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PIB) is an in vivo ligand for measuring beta-amyloid (Abeta) load. Associations between PET PIB and cerebrospinal fluid (CSF) Abeta1-42 and apolipoprotein E epsilon4 (APOE epsilon4) have been observed in several studies, but the relations between PIB uptake and other biomarkers of Alzheimer's disease (AD) are less investigated. METHOD: PET PIB, PET 18Fluoro-2-deoxy-D-glucose and different AD biomarkers were measured twice in CSF, plasma and urine 12 months apart in 10 patients with a clinical diagnosis of mild to moderate AD. RESULTS: PIB retention was constant over 1 year, inversely related to low CSF Abeta1-42 (p = 0.01) and correlated positively to the numbers of the APOE epsilon4 allele (0, 1 or 2) (p = 0.02). There was a relation between mean PIB retention and CSF ApoE protein (r = -0.59, p = 0.07), and plasma cystatin C (r = -0.56, p = 0.09). CONCLUSION: PIB retention is strongly related to CSF Abeta1-42, and to the numbers of the APOE epsilon4 allele.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Aged
- Alzheimer Disease
- metabolism
- radionuclide imaging
- Amyloid beta-Protein
- blood
- cerebrospinal fluid
- urine
- Aniline Compounds
- analysis
- metabolism
- Apolipoproteins E
- genetics
- Biological Markers
- blood
- cerebrospinal fluid
- urine
- Brain
- radionuclide imaging
- Cognition
- physiology
- Data Interpretation
- Statistical
- Education
- Enzyme-Linked Immunosorbent Assay
- Female
- Glucose
- metabolism
- Humans
- Male
- Middle Aged
- Neuropsychological Tests
- Positron-Emission Tomography
- Psychiatric Status Rating Scales
- Psychometrics
- Radiopharmaceuticals
- diagnostic use
- Risk Factors
- Thiazoles
- analysis
- metabolism
- Pittsburgh Compound-B
- Psychology
- Psychology
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Degerman Gunnars ...
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Lindau, Maria
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Wall, Anders
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Blennow, Kaj, 19 ...
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Darreh-Shori, T
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Basu, Samar
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Nordberg, A
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Larsson, Anders
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Lannfelt, Lars
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Basun, H
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Kilander, Lena
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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Dementia and ger ...
- By the university
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University of Gothenburg
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Stockholm University
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Uppsala University
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Karolinska Institutet